Symbol
Name
ID

Rbpj
recombination signal binding protein for immunoglobulin kappa J region
MGI:96522

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Leukopenia	Splenomegaly	Hypersplenism
Disease(s) Associated with RBPJ
Adams-Oliver syndrome

Mouse Phenotypes

immune system phenotype

aortic valve inflammation

increased T cell proliferation

small thymus

decreased thymocyte number

abnormal lymphopoiesis

abnormal B cell differentiation

abnormal T-helper 2 cell differentiation

increased double-negative T cell number

decreased double-positive T cell number

arrested T cell differentiation

increased plasmacytoid dendritic cell number

decreased dendritic cell number

decreased marginal zone B cell number

increased follicular B cell number

increased B cell number

decreased single-positive T cell number

increased T cell number

increased single-positive T cell number

increased macrophage cell number

increased monocyte cell number

abnormal CD4-positive helper T cell morphology

increased splenocyte number

increased IgG3 level

abnormal regulatory T cell physiology

decreased follicular dendritic cell number

abnormal immune system physiology

abnormal humoral immune response

abnormal cytokine secretion

decreased interleukin-4 secretion

abnormal response to infection

increased susceptibility to bacterial infection

increased susceptibility to bacterial infection induced morbidity/mortality

Availability

Mouse Genotype

Rbpj^tm1Hon/Rbpj^tm1Hon

Rbpj^tm1Kyo/Rbpj^tm1Kyo

Rbpj^tm1Kyo/Rbpj⁺

Cd19^tm1(cre)Cgn/Cd19⁺
Rbpj^tm1Hon/Rbpj^tm1Hon (conditional)

Rbpj^tm1Hon/Rbpj^tm1Hon
Tg(Mx1-cre)1Cgn/0 (conditional)

Rbpj^tm1Hon/Rbpj^tm1Hon
Tg(Itgax-cre)1-1Reiz/0 (conditional)

Rbpj^tm1Hon/Rbpj^tm1Hon
Tg(Cd4-cre)1Cwi/? (conditional)

Rbpj^tm1Hon/Rbpj^tm1Hon
Tg(Lck-cre)19Hhan/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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